University of Wisconsin, Madison, USA
Associate Professor (tenured), Division of Geriatrics and Gerontology, Department of Medicine, UW SMPH, and Health Science Officer, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital Madison.
Dr. Anderson leads the Metabolism of Aging research program at the University of Wisconsin Madison Department of Medicine in the School of Medicine and Public Health. Her work on aging and delayed aging by caloric restriction began in unicellular eukaryotes during her post-doc in Harvard Medical School, Boston MA, and extended into mammalian systems at the UW Madison Institute on Aging and at the Wisconsin National Primate Research Center. Dr. Anderson is Co-PI of the Caloric Restriction and Aging in Rhesus Monkeys study which was the first to demonstrate the translatability of mechanisms of delayed aging by caloric restriction to primate species. She is Associate Director of the UW Madison T32 Biology of Aging training grant program and Co-Director of the Cellular and Molecular Biology of Aging course. Dr. Anderson is a recipient of the Nathan Shock New Investigator Award from the Gerontological Society of America, The Glenn Award for Research in Biological Mechanisms of Aging, and a recipient of the Breakthroughs in Gerontology Award from the American Federation for Aging Research and the Glenn Foundation for Medical Research.
University of Groningen, NL
Barbara Bakker studied biochemistry at the University of Amsterdam and did her PhD in systems biology ‘avant la lettre’ at the VU University Amsterdam. Since 2009 she is a group leader at the University Medical Center Groningen. The Bakker group applies systems biology approaches closely to the clinic, to inborn errors of metabolism and age-related metabolic diseases, focusing on the interplay between lipid and carbohydrate metabolism. Barbara Bakker was awarded the yearly prize of the Netherlands Society for Biochemistry and Molecular Biology (2003) and a Rosalind Franklin award from the University of Groningen (2009). She is a board member of the Dutch research school for Bioinformatics and Systems Biology (BioSB), the chair of the International Study Group for Systems Biology, and one of the founders of the Systems Biology Centre for Metabolism and Ageing in Groningen.
University of California, San Diego, USA
Michael Burkart grew up in Texas received a BA from Rice University in 1994 and PhD from the Scripps Research Institute in 1999, followed by postdoctoral studies at Harvard Medical School. He began research at UC San Diego in 2002 and is currently the Teddy Traylor Faculty Scholar and Vice-Chair of Chemistry and Biochemistry. His lab pursues research in natural product biosynthesis and metabolic engineering.
University of Illinois at Urbana-Champaign, USA
John Cronan is Professor and Head, Department of Microbiology and Professor of Biochemistry at the University of Illinois. He has long studied bacterial lipid synthesis including the early steps of CoA synthesis and the attachment of the CoA phosphopantetheine moiety to acyl carrier proteins.
Stellenbosch University, South Africa
Marianne is a South African who completed a PhD in 2009 at Stellenbosch University, SA, in the field of Coenzyme A biosynthesis as antimicrobial drug target. She has since conducted postdoctoral work in the biocatalysis group of Prof. Gerrit Poelarends at the University of Groningen, NL, followed by postdoctoral work in the cell biology group of Prof. Ody Sibon at the University Medical Centre Groningen, NL. She relocated back to South Africa and in 2014 received a Research Career Advancement fellowship from the National Research Foundation of South Africa to start her own research group. Marianne is currently appointed as full-time lecturer in the Department of Biochemistry at Stellenbosch University. The focus of her research group is on the mode of action of pantothenate analogues as antimalarials in Plasmodium falciparum.
University of Cape Town, South Africa
Joanna Evans is a Research Officer in the Molecular Mycobacteriology Research Unit (MMRU), housed within the Institute of Infectious Disease and Molecular Medicine (IDM) at the University of Cape Town, where her research focuses on tuberculosis drug discovery and development. Recent work has included investigation of the coenzyme A biosynthesis pathway of Mycobacterium tuberculosis as a source of novel, vulnerable drug targets.
University of Bari, Italy
Positions and Employment
1990-1991: Fellow “Biotechnologies and Bioinstrumentations Finalized Project” CNR, Italy
1991-2001: Laureate technician “Department of Pharmaco-Biology, University of Bari, Italy
2001-2005: Researcher, “Department of Pharmaco-Biology, University of Bari, Italy
2005-2016: Associate Professor in Biochemistry, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy
10-1-2016: Full Professor in Biochemistry, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy
Other Experience and Professional Memberships
Visiting scientist at MRC, Laboratory of Molecular Biology, Cambridge, U.K. under the supervision of the Nobel Prize, Sir. John E. Walker in the following periods: 1/4/1991-26/7/1991; 3/11/1991-30/4/1992; 18/4/1994-17/5/1994; 2/2/1997-2/3/1997
1990 – Member, Italian Society of Biochemistry and Molecular Biology
1998 – ad hoc reviewer
2013 – Ad hoc reviewer for the Italian “Ministero dell’Istruzione, dell’Università e della Ricerca”
University of Kentucky, USA
Sylvie Garneau-Tsodikova obtained her Ph.D. in Chemistry in 2003 from the University of Alberta (Prof. John C. Vederas). She then pursued her postdoctoral studies with Prof. Christopher T. Walsh at Harvard Medical School. In 2006, Sylvie joined the University of Michigan as the John G. Searle Assistant Professor of Medicinal Chemistry at the College of Pharmacy and the Life Sciences Institute. In 2013, she relocated to the University of Kentucky as an Associate Professor of Pharmaceutical Sciences at the College of Pharmacy. She is an Associate Editor for MedChemComm (RSC journal) since its inception, and a member of the editorial boards of Journal of Biological Chemistry and ACS Infectious Diseases. She has published >125 manuscripts. She is the recipient of numerous research and teaching awards including the Vahlteich Research Award and NSF CAREER Award, the UK Blouin for teaching, the Award, William T. Miles Award for community service, and the 2017-2018 AAAS Leshner Fellowship for public engagement. She has given >60 invited talks and plenary lectures on her work around the world.
Wayne State University, USA
Miriam L. Greenberg is a Professor in the Department of Biological Sciences at Wayne State University, Detroit, Michigan. Her laboratory uses genetic, molecular, and biochemical approaches to elucidate the functions of the mitochondrial phospholipid cardiolipin, and the inositol phospholipids and metabolites. These studies have implications for understanding the pathology underlying cardiovascular disorders and the therapeutic mechanisms of action of drugs used in the treatment of psychiatric disorders.
St. Jude Children’s Research Hospital, USA
Suzy Jackowski is a Member of the faculty at St. Jude Children’s Research Hospital in Memphis, Tennessee, USA. Suzy has investigated the mechanisms that regulate CoA content in bacteria, cultured cells and knockout mice. The most recent effort has been focused on development of small molecule therapeutics for Pantothenate Kinase-Associated Neurodegeneration.
West Virginia University, USA
Roberta Leonardi, PhD, received her BS/MS in Chemistry from the Universita’ degli Studi di Catania, Italy, in 2000, and a PhD in Biochemistry from the University of Southampton, UK, in 2004. She then trained as a Postdoctoral fellow at St. Jude Children’s Hospital, Memphis, TN, working on the biosynthesis of coenzyme A (CoA) in pathogenic bacteria and mammals. In 2013, Dr. Leonardi joined the Biochemistry Department at West Virginia University as an Assistant Professor. Her laboratory currently works on CoA-degrading enzymes.
Dr. Meier received his undergraduate degree in chemistry from Creighton University in 2004, getting introduced to research as an National Science Foundation REU student. Following graduation he moved to the University of California-San Diego, performing graduate research in natural products biochemistry and proteomics under the mentorship of Professor Michael D. Burkart. After receiving his Ph.D. in chemistry in 2009, he moved to the California Institute of Technology. His research as an American Cancer Society postdoctoral fellow in the laboratory of Professor Peter B. Dervan focused on the development of high-throughput sequencing methods to analyze small molecule-DNA interactions. In 2013, Dr. Meier joined the NCI, where his research focuses on the development of chemical probes to investigate metabolic and epigenetic signaling pathways in cancer.
Centre d’Immunologie de Marseille-Luminy, France
Philippe Naquet (MD, PhD) is Professor in Immunology at Aix Marseille University and PI at the Centre d’Immunologie de Marseille Luminy. Current research interest explores the links between metabolism and inflammation through the exploration of the pantetheinase pathway and its applications to pathology.
Tulane University, USA
I am an associate professor in the Department of Biochemistry & Molecular Biology at Tulane School of Medicine. Interested in studying structure-function relationship of medically important proteins by crystallographic, biophysical and biochemical techniques as well as cell-based assays.
University of Wisconsin, Madison USA
Luigi Puglielli, MD, PhD is a Professor of Medicine and Neuroscience at the University of Wisconsin-Madison (USA). He completed his education at the Catholic University (Rome, Italy) and his post-doctoral training at the Center for Advanced Biomedical research of Boston University (Boston, MA, USA). He began his independent career at Harvard Medical School/Massachusetts General Hospital (Boston, MA, USA) and joined the University of Wisconsin-Madison (WI, USA) in 2003.
Dr. Puglielli’s research program focuses broadly on molecular mechanisms of neurodevelopment and neurodegeneration. His laboratory employs a combination of biochemical, cellular, molecular, and genetic approaches in in vitro, ex vivo and in vivo models. In 2007, his group reported that nascent proteins could undergo Nε-lysine acetylation in the lumen of the endoplasmic reticulum (ER). This discovery resulted in the identification of a previously unknown biochemical machinery that impacts on reticulophagy and proteostasis.
A central discovery of the Puglielli laboratory is the fact that influx of acetyl-CoA within the ER regulates the efficiency of the secretory pathway as well as the cross-talk between different intracellular organelles and compartments. A dysfunctional ER acetylation machinery has been linked to developmental delay and premature death, autism spectrum disorder and intellectual disability, autosomal dominant spastic paraplegia-42, and Alzheimer’s disease. Dr. Puglielli’s laboratory has generated mouse models that mimic the above diseases and dissected relevant pathogenic pathways. These results support findings obtained from human-based studies and indicate that the intracellular flux of acetyl-CoA plays a crucial role in both neurodevelopmental and neurodegenerative diseases.
University of Geneva, Switzerland
Dominique Soldati-Favre obtained her PhD degree at the University of Zürich in 1990. She was then a postdoctoral Fellow at Stanford University, Assistant Professor at the University of Heidelberg and Reader at Imperial College London. Since 2004 she is Professor at the Department of Microbiology and Molecular Medicine and Vice-Dean for research since 2011. The major focus of her work is to decipher the molecular mechanisms underlining gliding motility and host cell invasion in the obligate intracellular parasites of the phylum of Apicomplexa. This journey led her so far to the molecular dissection of myosin motors, actin dynamics, adhesins, proteases and more recently lipid singling mediators and metabolism.
Foundation IRCCS Neurological Institute C. Besta, Italy
University of Milan − Biology degree cum laude: 1989.
University of Milan − Specialization in Medical Genetics cum laude: 2001.
Permanent position as Associate Professor, Unit of Molecular Neurogenetics, Foundation IRCCS Neurological Institute C. Besta
Dr. Valeria Tiranti has a long−standing expertise in mitochondrial and metabolic disorders, including identification of disease genes, biochemical evaluation of the respiratory chain activities, molecular and cellular biology, and identification of pathogenic mechanisms of diseases. Her group performed the characterization of different mouse models and attempted pharmacological treatments in some of them. She joined the NBIA field some years ago and she is trying to elucidate the role of mitochondria in neurodegeneration by studying cellular and animal models.
Foundation Neurological Institute C. Besta is an internationally recognized leading Centre in neuroscience; it diagnoses and treats neurological diseases in adults and children and carries out basic and clinical research in Neurology.
The Unit of Molecular Neurogenetics is dedicated to research and advanced diagnostic activities to offer a service of excellence to patients, and make progress toward the elucidation of the causes and mechanisms leading to mitochondrial diseases. The Unit is also devoted to the molecular genetics diagnosis of NBIA and other neurodegenerative diseases, such as Parkinson’s disease.
University of Texas Southwestern Medical Centre, USA
Ben Tu is in the Department of Biochemistry at the University of Texas Southwestern Medical Center at Dallas, Texas USA. His lab is interested in how cellular processes are coordinated with metabolism and the metabolic state of the cell, including those linked to acetyl-CoA.
University of Pennsylvania, USA
Nathaniel is an Assistant Professor at the A.J. Drexel Autism Institute. His current work focuses on identifying and measuring modifiable risk factors for autism spectrum disorder (ASD). More broadly, he is interested in the interplay between metabolism and health outcomes across many disease states. Additional projects include fundamental work on improving sample collection and analysis, as well as refining epidemiological trial design using laboratory measurements.
Nathaniel studied Biochemistry at the University of Maryland and trained at the National Institutes of Health. Dr. Snyder’s Ph.D. thesis in Pharmacology at the University of Pennsylvania concerned analytical measurements of low abundance biological molecules using liquid chromatography-mass spectrometry (LC-MS). Also completed at the University of Pennsylvania, Dr. Snyder’s MPH work investigated non-invasive biomarkers of asbestos exposure, and contributed to the Penn Superfund Research and Training Program.
Johns Hopkins University, USA
Dr. Michael Wolfgang is an Associate Professor of Biological Chemistry at the Johns Hopkins University School of Medicine.
Dr. Wolfgang’s laboratory is interested in determining the biological roles of unexplored metabolic enzymes and deciphering novel roles of cannonical metabolic pathways.